P3-091 Regional distribution of white matter changes in Alzheimer's disease
نویسندگان
چکیده
منابع مشابه
Early white matter changes in Wilson disease.
We describe a 12 years old male who presented with one year history of cognitive decline with extrapyramidal features. Wilson disease was diagnosed on basis of biochemical studies and MRI. MRI showed increased signal intensity on T2 weighted images in basal ganglia and supratentorial with infratentorial gray and white matter. Our patient developed white matter changes early in course of disease.
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Cigarette smoking is highly prevalent in the general population but the effects of chronic smoking on brain structures are still unclear. Previous studies have found mixed results regarding regional grey matter abnormalities in smokers. To characterize both grey and white matter changes in heavy male smokers, we investigated 16 heavy smokers and 16 matched healthy controls, using both univariat...
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BACKGROUND White matter hyperintensities (WMH) on MRI scans indicate lesions of the subcortical fiber system. The regional distribution of WMH may be related to their pathophysiology and clinical effect in vascular dementia (VaD), Alzheimer's disease (AD) and healthy aging. METHODS Regional WMH volumes were measured in MRI scans of 20 VaD patients, 25 AD patients and 22 healthy elderly subjec...
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L. Wang, F. C. Goldstein, L. Li, J. J. Lah, A. I. Levey, and H. Mao Department of Radiology, Emory University School of Medicine, Atlanta, GA, United States, Department of Radiology, The Second Hospital of Shenzhen, Shenzhen, Guangdong, China, People's Republic of, Department of Neurology, Emory University School of Medicine, Department of Biomedical Engineering, Emory University School of Medi...
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BACKGROUND Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Current avenues of AD research focus on pre-symptomatic biomarkers that will assist with early diagnosis of AD. The majority of magnetic resonance imaging (MRI) based biomarker research to date has focused on neuronal loss in grey matter and there is a paucity of research on white matter. METHODS Longitudinal DTI...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2004
ISSN: 0197-4580
DOI: 10.1016/s0197-4580(04)81243-0